Ivan Still, PhD
Assistant Professor of Biology
1988 BSc (Hons) Biochemistry, Second Division, Upper Class. University College London UK.
1992 PhD in Human Genetics. University of Newcastle-upon-Tyne, UK
Title: Isolation of novel genes expressed during retinal development.
BIOL 1114 Principles of Biology
BIOL 4033 Cell Biology
BIOL 4083 Cancer Biology
BIOL 4891 Seminar in Biology
BIOL 4992 Undergraduate research projects in cell and molecular biology
Coming to University is an exciting period in a student’s life. He/she is about to experience a number of things for the very first time, foremost of all is their chosen Major! I believe in encouraging student not only to learn the subject matter but also to critically interpret and examine the underlying data: in other words to think about the subject. While knowledge is a fundamental requirement in all academic situations, later on it is the ability to think laterally and apply the knowledge gained during the student’s formative years that is ultimately important in the future career of the graduating student. I bring this to the fore both in the class setting and when I mentor students in one-to-one situations. My door is always open to students so that I may help them in any way I can.
General Research InterestS
Molecular basis of cancer.
Control of transcription mediated by nuclear hormone receptors, coregulators and chromatin structure.
Mechanisms of DNA damage induced by polyaromatic hydrocarbons
Muscle cell differentiation
Molecular evolution of protein-protein interactions
Current program: Characterization of the Transforming Acidic Coiled Coil (TACC) gene family.
In 1998, I discovered and published a new family of proteins that are important in the development of cancer. From 2000-2006, my research team (at Roswell Park Cancer Institute) explored the role of these Transforming Acidic Coiled Coil proteins in the interphase nucleus, and the role they play in cell cycle checkpoint activation that occurs during DNA damage. These goals are being furthered here to provide a coherent picture of how dysregulation, alteration of splicing patterns or mutations of the TACC genes adversely affects normal cellular metabolism and contributes to the development and progression of cancer.
UNDERGRADUATE RESEARCH STUDENTS SUPERVISED (Arkansas Tech).
Mentored research is important in the development of future graduate and medical students. So every Fall and Spring semester I encourage one or two junior or senior students to participate in my TACC-related projects. These projects have ranged from exploring the use of the Affymetrix Exon array to identify novel breast cancer biomarkers, to targeted knock-out of genes in muscle cells. More recently, we have opened up collaborations with Dr. Gavin Jones in the Department of Chemistry to test the anticancer activity of newly made organic compounds. Research projects of this nature underlie medicine and the pharmaceuticals industry and show the intimate relationship between chemistry and biology. These research projects have been funded by the generous support of the ATU undergraduate research program and the Arkansas Space Grant Consortium.
High School Students Supervised
SELECTED REFEREED PUBLICATIONS (From 27)
13. Kunapuli P, Somerville R, Still IH, and Cowell J.K. (2003). The ZNF198 gene, involved in rearrangement in myeloproliferative disease, forms complexes with HHR6A/6B and RAD18, implicating it in the post replication DNA repair process. Oncogene 22: 3417-3423
15. Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Wong FH, Lin WJ, Still IH, Huang CY (2004). Identification of the substrates of Aurora kinases from a protein-protein interaction model. Mol. Cell. Proteomics 3:93-104.
16. Gangisetty O, Lauffart B, Sondarva, G, Chelsea D, and Still IH. (2004). The Transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Oncogene 23:14:2559-2563.
17. Still IH, Vettaikkorumakankauv AK, Dimatteo A, and Liang P. (2004). Structure-function evolution of the Transforming acidic coiled genes revealed by analysis of phylogenetically diverse organisms. BMC Evolutionary Biology 4: 16
18. Singh KK, Kulaweic M, Still I, Desouki MM, Geradts, J and Matsui S-I. (2005). Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorgenesis. Gene 354:140-6.
20. Lauffart B, Dimatteo A, Vaughan MM, Cincotta M, Black JD and Still IH. (2006). Temporal and spatial expression of TACC1 in the mouse and human. Developmental Dynamics 235:1638-1647
21. Kulawiec M, Arnouk H, Desouki M , Kazim L, Still I and Singh KK. (2006). Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer cells. Cancer Biology and Therapy, 5: 967 – 968
22. Lauffart B, Sondarva G, Gangisetty O, Cincotta M, and Still IH. (2007). Interaction of TACC proteins with the FHL family: implications for ERK signaling. Journal of Cell Communication and Signaling 1:5-15.
23. Lauffart B, Gangisetty O, and Still IH. (2007). Evolutionary conserved interaction of TACC2/TACC3 with BARD1 and BRCA1: potential implications for DNA damage response in breast and ovarian cancer. Cancer Therapy 5:409-416.
24. Kulawiec M, Safina A, Desouki MM, Still IH, Matsui S-I, Bakin A, and Singh KK. (2008). Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biology & Therapy 7:1732-1743.
25. Vettaikkorumakankauv AK, Lauffart B, Gangisetty O, Cincotta M, Hawthorne LA, Cowell JK and Still IH. (2008). The TACC proteins are coregulators of the retinoid-X receptorb. Cancer Therapy 6:805-816.
26. Still IH, Eslinger MR, Lauffart B . (2009). TACC1 (transforming, acidic coiled-coil containing protein 1). Atlas Genet Cytogenet Oncol Haematol. (REVIEW). URL : http://AtlasGeneticsOncology.org/Genes/TACC1ID42456ch8p11.html
27. Eslinger MR, Lauffart B, Still IH. (2009). TACC3 (transforming, acidic coiled-coil containing protein 3). Atlas Genet Cytogenet Oncol Haematol. (REVIEW) URL : http://AtlasGeneticsOncology.org/Genes/TACC3ID42458ch4p16.html
1. Cleveland State University 2006 Talk entitled: “aTACCking a new gene’s role in cancer”
2. Arkansas Tech University 2006 Talk entitled: “aTACCking a new gene’s role in cancer”
Key Note Speaker, Arkansas Junior Science and Humanities Symposium March
4. Arkansas Tech University 2009 (April 2) Talk entitled: “Wanderlust: how a cancer metastasizes”
5. University of The Ozarks 2009 (September 25) Talk entitled: “A decade of TACCs: have we pinned down their functions yet?”
American Association for Cancer Research
Arkansas Academy of Sciences
Managing Editor, Journal of the Arkansas Academy of Science.
Marquis Who's Who in America, Editions 55-60
Marquis Who's Who in Science and Engineering, Editions 2005, 2006, 2007, 2008 (10th Anniversary)
Who's Who Among American Teachers & Educators 11th Edition (2007)
Copyright © Arkansas Tech University, Russellville, Arkansas.